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pentobarbital will lower the extent or impact of fesoterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lessen the extent or impact of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a delicate CYP3A4 substrate. Coadministration w